Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 016] Prognostic impact of serum soluble PD-1 and ADV score for living donor liver transplantation in patients with previously untreated hepatocellular carcinoma
Shin HWANG*1 , Deok-Bog MOON1 , Gi-Won SONG1 , Dong-Hwan JUNG1 , Kyung Jin LEE2 , Yun Kyu KIM2 , Hunji YANG2 , Da Eun AN2 , Sion LEE2
1 Department Of Surgery, Asan Medical Center, University Of Ulsan College Of Medicine, REPUBLIC OF KOREA
2 Asan Institute Of Life Sciences, Asan Medical Center, University Of Ulsan College Of Medicine, REPUBLIC OF KOREA
Background : The programmed death protein 1 (PD-1) pathway is the critical mechanism in development of hepatocellular carcinoma (HCC). The present study analyzed the prognostic impact of pretransplant serum soluble PD-1 (sPD-1) concentration and α-fetoprotein? des-γ-carboxyprothrombin?tumor volume (ADV) score in patients with previously untreated HCC undergone liver transplantation (LT). o
Methods : This retrospective single-center study enrolled 100 patients with HCC who underwent living donor LT from 2010 to 2016. Concentrations of sPD-1 were measured in stored serum samples.
Results : Receiver operating characteristic curve analysis of 2-year tumor recurrence resulted in an sPD-1 cutoff of 177.1 킽/mL, which was associated with higher rates of tumor recurrence (p = 0.022), but not with overall patient survival (p = 0.460). The derived cutoff for pretransplant ADV score was 5.4log, which was associated with higher tumor recurrence rate (p < 0.001) and lower overall patient survival rate (p < 0.001). Both sPD-1 >177.1 킽/mL (hazard ratio [HR] = 2.26, p = 0.020) and pretransplant ADV score >5.4log (HR = 3.56, p < 0.001) were independent risk factors for post-transplant HCC recurrence. The combination of these two factors enabled the stratification of patients into three groups, with groups having 0, 1 and 2 risk factors differing significantly in the prognosis of tumor recurrence (p < 0.001) and overall patient survival (p = 0.006).
Conclusions : Both sPD-1 concentration and ADV score have prognostic impacts in patients who underwent LT for untreated HCCs. These factors, both individually and combined, can help in predicting post-transplant prognosis.
Methods : This retrospective single-center study enrolled 100 patients with HCC who underwent living donor LT from 2010 to 2016. Concentrations of sPD-1 were measured in stored serum samples.
Results : Receiver operating characteristic curve analysis of 2-year tumor recurrence resulted in an sPD-1 cutoff of 177.1 킽/mL, which was associated with higher rates of tumor recurrence (p = 0.022), but not with overall patient survival (p = 0.460). The derived cutoff for pretransplant ADV score was 5.4log, which was associated with higher tumor recurrence rate (p < 0.001) and lower overall patient survival rate (p < 0.001). Both sPD-1 >177.1 킽/mL (hazard ratio [HR] = 2.26, p = 0.020) and pretransplant ADV score >5.4log (HR = 3.56, p < 0.001) were independent risk factors for post-transplant HCC recurrence. The combination of these two factors enabled the stratification of patients into three groups, with groups having 0, 1 and 2 risk factors differing significantly in the prognosis of tumor recurrence (p < 0.001) and overall patient survival (p = 0.006).
Conclusions : Both sPD-1 concentration and ADV score have prognostic impacts in patients who underwent LT for untreated HCCs. These factors, both individually and combined, can help in predicting post-transplant prognosis.
SESSION
E-poster
E-Session 03/03 ~ 03/05 ALL DAY