Detailed Abstract
[BP Poster Presentation 2 - Biliary & Pancreas (Pancreas Disease/Surgery)]
[BP PP 2-2] Prognostic factors and recurrence pattern for long term survivors in patients with pancreatic cancer
Young Hoon ROH1 , Woohyung LEE*1 , Yoo Na LEE1 , Yong Jae KWON1 , Yun Beom RYU1 , Min Kyu SUNG1 , Dakyum SHIN1 , Sarang HONG1 , Yejong PARK1 , Bong Jun KWAK1 , Ki Byung SONG1 , Jae Hoon LEE1 , Dae Wook HWANG1 , Song Cheol KIM1
1 Division Of Hepatobiliary And Pancreatic Surgery, Department Of Surgery, University Of Ulsan College Of Medicine, Asan Medical Center, Seoul, REPUBLIC OF KOREA
Background : Although the number of long-term survivors have increased due to improved systemic chemotherapy for pancreatic ductal adenocarcinoma (PDAC), prognostic factors and recurrence patterns for long-term survivors more than 5 years are rarely reported.
Methods : We found patients who underwent curative intent surgery for PDAC with follow-up more than 5 years in a tertiary referral center between January 2000 and December 2015. Long term survivors were defined as patients who survived 5 years or more, and the characteristics of long-term survivors and recurrence patterns were investigated according to the each stage using 8th edition of American Joint on Cancer Committee staging system.
Results : Of 1837 patients, 253 (13.7 %) patients survived more than 5 years, and 175 (9.5%) patients did not relapse for more than 5 years. Long term survivors showed old age (75.6 vs 58.5, p<0.001), and higher preoperative albumin levels (3.9g/dL vs 3.6g/dL, p<0.001) compared with patients who expired within 5 years in stage I. Old age (75.4 vs 58.5, p<0.001), less frequent PNI (72.1% vs 83.0%, p=0.004), and adjuvant chemotherapy (100% vs 81.6%, p<0.001) were factors in long term survivors with stage II. In stage 3, Old age (75.7 vs 59.5, p<0.001), and adjuvant chemotherapy (100% vs 85.4%) were related with long term survival. Even in patients who did not recurrence for more than 5 years, recurrence occurred over 96.9 months, and the most common sites of recurrence were liver (25.2%), peritoneum (17.6%), and lung (9.2%).
Conclusions : Old age and adjuvant chemotherapy were related with long term survival. Follow-up more than 5 years is necessary even for long term survivors because of frequent recurrence after 5 years.
Methods : We found patients who underwent curative intent surgery for PDAC with follow-up more than 5 years in a tertiary referral center between January 2000 and December 2015. Long term survivors were defined as patients who survived 5 years or more, and the characteristics of long-term survivors and recurrence patterns were investigated according to the each stage using 8th edition of American Joint on Cancer Committee staging system.
Results : Of 1837 patients, 253 (13.7 %) patients survived more than 5 years, and 175 (9.5%) patients did not relapse for more than 5 years. Long term survivors showed old age (75.6 vs 58.5, p<0.001), and higher preoperative albumin levels (3.9g/dL vs 3.6g/dL, p<0.001) compared with patients who expired within 5 years in stage I. Old age (75.4 vs 58.5, p<0.001), less frequent PNI (72.1% vs 83.0%, p=0.004), and adjuvant chemotherapy (100% vs 81.6%, p<0.001) were factors in long term survivors with stage II. In stage 3, Old age (75.7 vs 59.5, p<0.001), and adjuvant chemotherapy (100% vs 85.4%) were related with long term survival. Even in patients who did not recurrence for more than 5 years, recurrence occurred over 96.9 months, and the most common sites of recurrence were liver (25.2%), peritoneum (17.6%), and lung (9.2%).
Conclusions : Old age and adjuvant chemotherapy were related with long term survival. Follow-up more than 5 years is necessary even for long term survivors because of frequent recurrence after 5 years.
SESSION
BP Poster Presentation 2
Poster Presentation 3/3/2022 3:20 PM - 4:20 PM