Detailed Abstract
[E-poster - Liver (Liver Disease/Surgery)]
[EP 023] Long-term oncologic prognosis after hepatectomy for hepatocellular carcinoma: Differences between the young (≤ 35 years old) and the elderly (≥ 70 years old) s
Jia-Le PU1 , Zhong CHEN1 , Lan-Qing YAO2 , Ji-Ye FENG3 , Yong-Kang DIAO4 , Feng SHEN2 , Timothy M. PAWLIK5 , Wan Yee LAU2 , Tian YANG*2
1 Hepatobiliary Surgery, The First Affiliated Hospital Of Nantong University, CHINA
2 Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, CHINA
3 Hepatobiliary Surgery, The Affiliated People's Hospital Of Ningbo University, CHINA
4 Hepatobiliary Surgery, Zhejiang Provincial People's Hospital, People's Hospital Of Hangzhou Medical College, CHINA
5 Surgery, Ohio State University, Wexner Medical Centre, UNITED STATES OF AMERICA
Background : While hepatocellular carcinoma (HCC) is the most common malignancy in the elderly worldwide, it is also common among younger individuals in areas with endemic hepatitis B virus infection. The characterized differences in long-term oncological prognosis among young versus elderly patients after R0 liver resection for HCC were sought in this study.
Methods : Using a Chinese multicentre database, consecutive patients who underwent R0 liver resection for HCC between 2007 and 2019 were retrospectively analysed. After excluding middle-aged (36~69 years old) patients, overall survival (OS), cancer-specific survival (CSS), and time-to-recurrence (TTR) were compared between young (≤35 years old) versus elderly (≥70 years old) patients using propensity score matching (PSM). a
Results : Among 531 enrolled patients, there were 192 (36.2%) and 339 (63.8%) patients categorized as young versus elderly, respectively. PSM analysis created 140 pairs of matched patients. In the PSM cohort, 5-year OS was comparable among young versus elderly patients (51.7%vs.52.3%, P=0.533). Young patients did, however, had a higher 5-year TTR (62.1% vs. 51.6%, P=0.011) and a worse 5-year CSS (54.0%vs.64.3%, P=0.034) than elderly patients. On multivariable Cox-regression analyses, young patient age remained independently associated with an increased TTR rate (HR 1.62, P=0.016) and a decreased CSS rate (HR 1.69, P=0.021) compared with elderly patients.
Conclusions : Following R0 liver resection for HCC, younger patients were at a higher risk of recurrence, yet elderly patients had a better CSS rate. Thus, enhanced surveillance for HCC recurrence should be implemented for young patients.
Methods : Using a Chinese multicentre database, consecutive patients who underwent R0 liver resection for HCC between 2007 and 2019 were retrospectively analysed. After excluding middle-aged (36~69 years old) patients, overall survival (OS), cancer-specific survival (CSS), and time-to-recurrence (TTR) were compared between young (≤35 years old) versus elderly (≥70 years old) patients using propensity score matching (PSM). a
Results : Among 531 enrolled patients, there were 192 (36.2%) and 339 (63.8%) patients categorized as young versus elderly, respectively. PSM analysis created 140 pairs of matched patients. In the PSM cohort, 5-year OS was comparable among young versus elderly patients (51.7%vs.52.3%, P=0.533). Young patients did, however, had a higher 5-year TTR (62.1% vs. 51.6%, P=0.011) and a worse 5-year CSS (54.0%vs.64.3%, P=0.034) than elderly patients. On multivariable Cox-regression analyses, young patient age remained independently associated with an increased TTR rate (HR 1.62, P=0.016) and a decreased CSS rate (HR 1.69, P=0.021) compared with elderly patients.
Conclusions : Following R0 liver resection for HCC, younger patients were at a higher risk of recurrence, yet elderly patients had a better CSS rate. Thus, enhanced surveillance for HCC recurrence should be implemented for young patients.
SESSION
E-poster
E-Session 03/03 ~ 03/05 ALL DAY